The “Unit of Pathogenesis and Treatment of Immune and Bone Diseases” lab, led by Anna Villa at the San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Milan, Italy is recruiting a highly motivated post-doctoral fellow with strong experience in hematopoietic stem cell biology and bone marrow niche. The project will be focused on the study of ectopic bone marrow niche and optimization of innovative gene correction platform. The research activities of our laboratory are focused on the study of pathological mechanisms of immune and bone diseases and the preclinical evaluation of innovative therapeutic approaches based on gene therapy, gene editing and novel conditioning regimens. As part of the SR-TIGET, a world-leading Institute in the field of gene and cell therapy for the treatment of human genetic diseases, we benefit from a highly competitive, international and scientifically stimulating environment and offer excellent state-of-the-art facilities and infrastructures, and access to clinically relevant human samples.

The “Unit of Pathogenesis and Treatment of Immune and Bone Diseases” lab, led by Anna Villa at the San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Milan, Italy is recruiting a talented and motivated research fellow. The project will be focused on the study of ectopic bone marrow niche and optimization of innovative gene correction platform. The research activities of our laboratory are focused on the study of pathological mechanisms of immune and bone diseases and the preclinical evaluation of innovative therapeutic approaches based on gene therapy and novel conditioning regimens. As part of the SR-TIGET, a world-leading Institute in the field of gene and cell therapy for the treatment of human genetic diseases, we benefit from a highly competitive, international and scientifically stimulating environment and offer excellent state-of-the-art facilities and infrastructures, and access to clinically relevant human samples.

Why do many cancer patients develop delayed metastases? How do metastatic cells survive in a foreign environment? Can we identify disseminated cancer cells before metastatic outgrowth? If you are interested in answering these questions, Montagner lab is looking for two creative, independent, and ambitious Postdocs. Our mission is to identify innovative actionable targets to kill disseminated metastatic cells before the onset of metastasis. In our lab we apply bulk (qPCR, western blotting, cytofluorimetry) and single cell analyses (scRNAseq,immunofluorescence, multispectral imaging, mass cytometry) which encompass a breadth of disciplines (molecular biology, biochemistry, mechanobiology, bioinformatics, optogenetics) spanning diverse areas (cell biology, genomics, and metabolomics, pre-clinical translation, liquid biopsies). The Postdocs will isolate disseminated cells from multiple sources and animal models, generate single cell expression profiles, characterize the microenvironment, develop organotypic systems in vitro and design experiments for orthogonal validation or functional studies (patient-derived cell lines, high content screens, animal models) using technologies available through our group and our collaborators.(Montagner et al., Nature Cell Biology 2020; Zangrossi et al., Cancers 2021; Zangrossi et al., Cancers 2021).

Interested in understanding how blood cells form? A postdoctoral position is available in the laboratory of Dr. Andrea Ditadi at SR-TIGET (Telethon Institute for Gene Therapy at the Ospedale San Raffaele) in Milan to study new layers of regulation of blood development.

The Laboratory of Computational Modeling at the University of Trento (CIBIO Department, PI Luca Marchetti), in collaboration with Fondazione COSBI, is seeking for a postdoctoral researcher,with previous experience in computational modeling projects, to foster a joint investigation effort in computational modeling of mRNA-based products(vaccines and monoclonal antibodies), in the context of the International Wellcome Leap project “R3: RNA Readiness and Response".

A post-doctoral position is available in Stefan Schoeftner’s laboratory in the Department of Life Sciences at the University of Trieste (Italy).Research in the Schoeftner laboratory is focusing on non-coding RNA biology, genomic instability and the development of patient derived tumor organoid models.

Position as Postdoctoral Research Fellow available at the Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo in the research group of Professor Cinzia Progida. No one can be appointed for more than one Postdoctoral Research Fellowship at the University of Oslo. The appointment is a fulltime position and is made for a period of three years (10% of which is devoted to required duties, usually in the form of teaching activities). The candidate for this position will work on a project funded by the Norwegian Cancer Society. In this project, we aim to unravel the role of the endoplasmic reticulum-focal adhesions contact sites in transducing external cues to the nucleus, leading to altered gene expression, and how this is coupled with the development of the cancer cell invasive ability during cancer progression. To achieve this, the project will make use of RNAi screens and advanced imaging techniques such as super-resolution and live imaging. Our group has access to the National imaging platform NorMIC Oslo, with a wide range of state-of-the-art imaging equipment. The Department of Biosciences harbors also an EM-lab, the Norwegian Sequencing Centre (NSC) and Proteomics services. The main purpose of a postdoctoral fellowship is to provide the candidates with enhanced skills to pursue a scientific top position within or beyond academia. To promote a strategic career path, all postdoctoral research fellows are required to submit a professional development plan no later than one month after commencement of the postdoctoral period.

Position as Researcher available at the Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo. The position is for a period of 3 years. The candidate will generate and analyze new, cutting-edge high-throughput sequencing data of three-dimensional (3D) genome reorganization during nuclear deformations. The goal is to unravel new mechano-transduction pathways linked to 3D genome reorganization in cancer. The candidate for this position will work on a project funded by the Norwegian Cancer Society. The work will be carried out in a cross-disciplinary collaboration between the research groups of Associate Professor Jonas Paulsen and Prof. Cinzia Progida. Building on bioinformatics software developed in Paulsen research group [Nature Protoc. 2018; Nature Genetics 2019], the data will be used to generate predictive computational models of 3D genome deformation and gene expression changes during different types of nuclear deformations. Imaging techniques, including super-resolution imaging, will be used to validate the models. The Department of Biosciences has access to state-of-the-art infrastructure, including a High-throughput sequencing facility (Norwegian Sequencing Centre), as well as an imaging facility (NorMIC)

We have discovered that cancers increase the production/accumulation of abnormal ncRNA, which activate the RNA sensing pathway in cells of the tumor microenvironment through extracellular vesicles (tEVs), (Biagini et al., submitted). The project, funded by AIRC (www.airc.it/english), aims at characterizing the effects of the RNA sensing pathway in tumors and associated immune cells using cell type specific approaches. We will identify the endogenous RNA species involved in signaling to the RNA sensing pathway, and the biogenesis of these ncRNA cargos in tEVs. We have fully funded post-doc and pre-doc/PhD positions to investigate the roles of the RNA sensing pathway in tumor progression and metastasis formation and identify drugs modulating this process.

The Laboratory of Computational Modeling at the University of Trento (CIBIO Department, PI Luca Marchetti), in collaboration with Fondazione COSBI, is seeking for: 1. a senior post-doc mathematical modeler, with previous consolidated experience in quantitative systems pharmacology (QSP) projects, with preferential knowledge in the area of mRNA-based products 2. a junior post-doc mathematical modeler, with experience in the area of mathematical modeling of biological processes to foster a joint investigation effort in mathematical QSP modeling of mRNA-based products, specifically vaccines and monoclonal antibodies (mAb), in the context of the International Wellcome Leap project “R3: RNA Readiness and Response”.