A Lab Technician/Research Assistant position is immediately available in the Process Development Lab (PDL), led by Marina Radrizzani at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy (https://research.hsr.it/en/institutes/san-raffaele-telethon-institute-for-gene-therapy/process-development-lab.html).
The Institute. SR-Tiget was created in 1996 as a joint-venture between Fondazione Telethon and Ospedale San Raffaele (OSR), with the mission to perform cutting edge research on gene and cell therapy and to translate its results into therapeutic advances for genetic diseases. The Institute is located within the OSR campus, which includes a large multi-disciplinary research hospital, a biomedical research center, a university and also hosts several biotechnologies companies. Over the years, SR-Tiget has given a pioneering contribution to the gene and cell therapy field with relevant discoveries in vector design, gene transfer and gene editing strategies, stem cell biology, identity and mechanism of action of regulatory cells in immune responses and innate immune cells in cancer. SR-Tiget has also established the resources and framework for translating these advances into novel experimental therapies and has implemented several successful gene therapy clinical trials, which have already treated >120 patients and led to the filing and approval of 2 novel advanced therapy medicines.
The position. We are looking for a motivated Lab Technician/Research Assitant to work in the PDL Vector Core, which is focused on process development, optimization and manufacturing of high-quality lentiviral vectors (LV) for in vitro and in vivo preclinical studies.

Main tasks

Downstream LV manufacturing processes, based on chromatography, tangential flow filtration, direct filtration
Downstream steps optimization and scale-up
Support to upstream LV manufacturing processes
Support to LV quality control: cell-based assays, molecular assays, flow cytometry analyses, ELISA
Preparation of standard lab procedures and protocols
General lab support

Qualifications and skills

Master Degree (Biology, Biotechnology or equivalent), PhD as a plus
Strong experience in chromatography techniques
Experience in Good Manufacturing Practices and/or LV production and quality control as a plus
High accuracy, reliability, precision
Friendly, collaborative, pro-active mindset
Good oral and written English

We offer

Competitive salary depending on qualifications and experience
A dynamic environment and the chance to give important contribution to innovative projects in the LV-based gene therapy field

Applications, including a CV and the name and contact details of at least one referee, should be sent by e-mail to radrizzani.marina@hsr.it and montaldo.elisa@hsr.it

Evaluation of applications/interviews will begin immediately and continue until the position is filled.