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Managing Board
Sara Sigismund
Department of Oncology and Hemato-oncology, University of Milan
Via Santa Sofia 9/1 - 20122 Milano
phone 02-574303285
Our lab studies the molecular mechanisms governing endocytosis and signaling of the epidermal growth factor receptor (EGFR), and how their alteration contributes to cancer development.
Board Members
Sirio Dupont
Università degli Studi di Padova
Department of Molecular Medicine
via Ugo Bassi 58/b - 35131 Padova
phone +390498276095
We are interested in understanding how the mechanical properties of the extracellular matrix (ECM) regulate signaling pathways, gene transcription and other cellular processes, and how this is relevant for cell behavior, tissue homeostasis and disease. Our goal is to identify novel general principles in vitro, and to push their validation in vivo with the development of new animal models to study mechano-signaling in tissues. We use a multidisciplinary approach that includes custom-built compliant cell culture substrata, ECM micropatterning, cell micromanipulations, optical microscopy, molecular and cell biology techniques, transcriptional and bioinformatic analyses, proteomics, metabolomics, CRISPR/Cas9 modified cell lines, and genetically-modified mice, also thanks to multiple collaborations with colleagues in Italy and abroad. We have identified YAP/TAZ transcriptional coactivators as readers of ECM mechanical cues and mediators of their effects on cancer cell proliferation and mesenchymal stem cell differentiation, and are now developing genetic tools to study the relevance of F-actin remodeling as regulator of YAP/TAZ activity in vivo. Moreover, we got recently interested in understanding how mechanical cues, YAP/TAZ and metabolism are reciprocally regulated.
Massimo Gulisano
University of Catania
Department of Drug and Health Sciences, Laboratory of Synthetic and Systems Biology
Viale Andrea Doria 6 - 95125 Catania
phone +390957384263 - fax +390952933700
My research interests are in the field of Synthetic and Systems Biology, with the following specific focuses: (1) experimental models for neurodegenerative and neuromuscular disorders (2) osteochondral stem cells and regenerative medicine using collagen/hydroxyapatite scaffolds (3) Epithelial Mesenchimal Transition (EMT) molecular mechanism in embryo development and cancer, using xenotransplant approaches in vertebrate embryos; (4) Drug screening strategies optimization in patient-derived organoid models
Letizia Lanzetti
Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Torino, Italy;
Department of Oncology, University of Torino Medical School, Torino, Italy.
Str. Provinciale 142 - 10060 Candiolo
phone 011 9933508

My research focuses on the crosstalk between endocytosis of oncogenic tyrosine kinase receptors and metabolic reprogramming in cancer cells.
Simona Paladino
University of Naples Federico II
Dept of Molecular Medicine and Medical Biotechnology
via Sergio Pansini, 5 - 80131 Napoli
phone 0817464574 - fax 081 7463308
My lab studies membrane trafficking in health and disease. Two main interests:
i) Role of endosomal trafficking in neurological disorders.
ii) Molecular mechanisms controlling the trafficking, membrane organization and functions of GPI-proteins in epithelial cells.
Giulia Piaggio
Regina Elena National Cancer Institute
Research, Diagnosis and Innovation Technologies
via Elio Chianesi 53 - 00144 Roma
phone +39 06 52662458
Transcriptional regulation of gene expression during cell proliferation, differentiation and transformation in living cells, tissues and animals in vivo.
Mouse models to follow biological processes by bioluminescence in vivo imaging (BLI) in living animals.
Anna Maria Porcelli
Affiliation to University of Bologna
Department of Pharmacy and Biotechnology
Via Francesco Selmi 3 - 40126 Bologna
phone 3408241175
My research interests are focused on the role of mitochondria and their DNA in metabolic and hypoxic adaptation during the different phases of tumorigenesis. In recent years, my research has aimed to define respiratory complex I as a modulator of tumour progression in vitro and in vivo models.