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Research Senior Technician/Technician at the laboratory of Dr Ana Casañal at the Structural Biology Research Centre (SBRC) at Human Technopole (HT)
Location
Human Technopole (HT)
Host Lab
Category
jobs / technician
Contract Duration
Salary
Deadline for application
Contact
ana.casanal@fht.org
 
The laboratory of Dr Ana Casañal at the Structural Biology Research Centre (SBRC) at Human Technopole (HT) is looking for a research Senior Technician/Technician https://humantechnopole.it/en/research-groups/casanal-group/.

The group is focused on the structural analysis (mainly by cryo-EM) of large macromolecular complexes involved in RNA processing. In particular, the Casañal lab uses an integrated structural biology approach that combines biochemistry, biophysics, and mass- spectrometry with structural biology techniques, to elucidate the molecular mechanisms behind the addition and the regulation of biochemical marks on RNA, a process often deregulated in human disease.

About the position
The motivated research Senior Technician/Technician will help with lab organisation/management, and will be involved in our structural biology research projects.
As research Senior Technician/Technician in the Casañal group, you will support our efforts in cloning, expression, purification, and biophysical characterisation of novel medically relevant protein complexes to be studied by cryo-EM or other structural methods.
You will be part of a highly collaborative and multidisciplinary environment, where we share a passion for exploring fundamental aspects of biology, share resources and expertise, and have access to excellent cryo-EM, biochemistry and biophysical facilities.

Your main tasks and responsibilities
  • Managing key aspects of general lab management and organisation (e.g., managing inventories and stocks of samples, equipment and materials, purchases, annual budget review, onboarding of students);
  • Conduct molecular biology, biochemistry, and biophysical experiments for structural studies;
  • Generate/improve new tools and protocols, performing pilot and screening experiments;
  • Generate reliable data for publication, record all data and results in specified forms (paper and electronic), and collaborate in writing papers;
  • Provide technical support and guidance to (junior) lab members;
  • Training researchers in instrumentation and/or technical procedures;
  • Work with external collaborators and maintain relationships with relevant research labs at HT.
Job requirements
Essential requirements:
  • B.Sc. in Chemistry, Biochemistry, Biology, Biotechnology, Molecular Biology or closely- related disciplines;
  • At least three years of proven practical experience in a molecular biology, biochemistry or structural biology laboratory;
  • Track record in the following areas: recombinant protein production and purification; molecular biology (DNA and/or RNA manipulation, cloning, sequencing), protein biochemistry (proficient use of AKTA systems, immunoprecipitation, western-blot);
  • Fluency in English - HT is an international research institute.

Preferred requirements:
  • Previous experience as a lab technician is desirable;
  • Experience in structural biology and/or bioinformatics;
  • Knowledge of biophysical techniques for the study of protein stability prior to structural biology studies.

Organizational and social skills:
  • Ability to manage competing priorities in a fast-paced environment and to work independently;
  • Ability and interest to learn or develop new methodologies;
  • Strong interpersonal skills demonstrated with a proven ability to effectively interact and collaborate with others as part of a team;
  • Ability to build trust through operating with transparency and creating an open and positive environment;
  • Ability to work in a multi-cultural, multi-ethnic environment with sensitivity and respect for diversity.

Application instructions:
To apply, please send the following:
  • a CV
  • a motivation letter in English relating your track record to the specifics of the call
  • names and contacts of 2 referees

Number of positions offered: 1
Contract offered: CCNL Chimico Farmaceutico, Fixed-term 3 years - employee level, with the possibility of renewal.
Salary range: up to 41K.
Tax benefits where applicable.
The position is based in Milan.


For further information on this opportunity: https://careers.humantechnopole.it/o/senior-techniciantechnician-casanal-group