Post doctoral position at Istituto Maugeri di Pavia

A postdoctoral position is open in the Gabellini laboratory at San Raffaele Scientific Institute to characterize the molecular pathogenesis of acute lymphoblastic leukemia and test novel therapeutic approaches.

Postdoctoral Researcher - Circuit Reconstruction & Regenerative Neuroscience (ERC CUSTOM_MADE) - NICO, Department of Neuroscience, University of Turin, Italy. The project aim to rebuild functional striatal circuits by grafting human striatal progenitors with optimized properties in preclinical models of Huntington’s disease, combining circuit-tracing with single-cell and spatial omics.

The successful candidate (H/F) will join Angela Taddei's team and work in close collaboration with Valérie Borde's team, both belonging to the Institut Curie Research Center and affiliated to the Nuclear Dynamics and Dynamics of Genetic Information departments respectively.

Research focuses on understanding how nuclear acyl-CoA metabolism influences chromatin remodeling and transcriptional regulation. Mitochondrial enzymes that produce acyl-CoAs, essential metabolites for chromatin modifications and gene activity, have been observed to be present and functional in the nucleus, where they generate metabolic niches that enhance local nuclear acyl-CoA synthesis, thereby impacting gene activity. This project uses omics-based approaches, metabolite tracing, proximity-labeling, and advanced imaging techniques to explore how these nuclear metabolic enzymes regulate gene expression, interact with chromatin factors, and contribute to nuclear organization and function.