A post-doctoral position is available in Stefan Schoeftner’s laboratory in the Department of Life Sciences at the University of Trieste (Italy).Research in the Schoeftner laboratory is focusing on non-coding RNA biology, genomic instability and the development of patient derived tumor organoid models.

Position as Postdoctoral Research Fellow available at the Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo in the research group of Professor Cinzia Progida. No one can be appointed for more than one Postdoctoral Research Fellowship at the University of Oslo. The appointment is a fulltime position and is made for a period of three years (10% of which is devoted to required duties, usually in the form of teaching activities). The candidate for this position will work on a project funded by the Norwegian Cancer Society. In this project, we aim to unravel the role of the endoplasmic reticulum-focal adhesions contact sites in transducing external cues to the nucleus, leading to altered gene expression, and how this is coupled with the development of the cancer cell invasive ability during cancer progression. To achieve this, the project will make use of RNAi screens and advanced imaging techniques such as super-resolution and live imaging. Our group has access to the National imaging platform NorMIC Oslo, with a wide range of state-of-the-art imaging equipment. The Department of Biosciences harbors also an EM-lab, the Norwegian Sequencing Centre (NSC) and Proteomics services. The main purpose of a postdoctoral fellowship is to provide the candidates with enhanced skills to pursue a scientific top position within or beyond academia. To promote a strategic career path, all postdoctoral research fellows are required to submit a professional development plan no later than one month after commencement of the postdoctoral period.

The Laboratory of Computational Modeling at the University of Trento (CIBIO Department, PI Luca Marchetti), in collaboration with Fondazione COSBI, is seeking for: 1. a senior post-doc mathematical modeler, with previous consolidated experience in quantitative systems pharmacology (QSP) projects, with preferential knowledge in the area of mRNA-based products 2. a junior post-doc mathematical modeler, with experience in the area of mathematical modeling of biological processes to foster a joint investigation effort in mathematical QSP modeling of mRNA-based products, specifically vaccines and monoclonal antibodies (mAb), in the context of the International Wellcome Leap project “R3: RNA Readiness and Response”.

The Laboratory of Computational Modeling at the University of Trento (CIBIO Department, PI Luca Marchetti), in collaboration with Fondazione COSBI, is seeking for: 1. a senior post-doc mathematical modeler, with previous consolidated experience in quantitative systems pharmacology (QSP) projects, with preferential knowledge in the area of mRNA-based products

The laboratory of Prof. Massimo M. Santoro at University of Padua is seeking a post-doctoral fellow to study the role of metabolism in cancer growth and spreading. Our lab has recently identified a set of novel metabolic enzymes that are crucial for the regulation of lipid metabolism and antioxidant response (Mugoni et al., Cell, Mugoni et al., Nature Protocols, Santoro, Cell Metabolism; Arslanbaeva and Santoro, Redox Biology, Facchinello et al.,Nature Metabolism, in press). Using mouse genetic approaches as well as advanced molecular and metabolic techniques we want to elucidate how lipids and metabolism regulate cancer survival and progression. Our laboratory has acquired strong experience in the field of metabolism, genetic, molecular and cellular biology working with cells and animal models.

The Research Strategy and Communication Office supports the SR-Tiget Director in a variety of strategic and operational activities, including strategic planning, reporting, internal and external communication. The Research Strategy and Communication Officer, reporting to the Research Strategy and Communication Manager, will provide highly organized and efficient support to the Office operations with a specific focus on the production of scientific content and documents, and organization of scientific events.

The aim of this project is to clarify the functional and structural relationships between respiratory complexes I and III to understand whether their supramolecular organization in supercomplexes can mitigate the effect of deleterious mutations in cytochrome b,one of the catalytic core subunits of complex III. To this purpose, biochemical approaches will be applied in human and bacterial cellular models carrying mutations in cytochrome b to analyze the structural stability and enzymatic activity of complex III in its isolated form or in assembled supercomplex I+III. The biochemical approaches will be associated with molecular dynamics simulations of supercomplex I+III by modeling wild type and mutated cytochrome b to obtain information on critical interactions between the two complexes for supercomplexes stability. From this project, we expect to obtain new knowledge on the structural and physiological relevance of supercomplexes healthy and pathological conditions.

PhD positions are available in the course of Medical-Surgery BioTechnologies and Translational Medicine in the lab of prof. Francesca Gioia Klinger, at University of Rome Tor Vergata, Department of Biomedicine and Prevention, Section of Histology and Embryology. The research lab focus mainly on advanced techniques to protect and preserve the ovarian reserve in human and in mice models. In line with this, the research concentrate on the discovery of new molecules to be used as fertoprotective agents and the use of mesenchymal stem cells and their released factors to improve and preserve the ovarian environment

This new project is focusing on new regulatory mechanisms of metabolism and their relevance for cancer metastasis, funded by a Worldwide Cancer Research grant. The current research of the lab is focused on mechanotransduction and how this regulates signaling and metabolism.

Aberrant sensing of nucleic acids originating from the expression of endogenous retroviral elements or accumulating DNA damage and consequent increase in type I IFN levels have been suggested to be a primary driver of pathogenesis of the Aicardi-Goutières Syndrome (AGS), a genetic Leukodystrophy that mainly affects the brain, immune system and skin. Nevertheless, the precise molecular mechanisms triggering the disease remain elusive. On these premises, we arerecruiting a post-doctoral fellow with strong experience in iPSC-based differentiation of Neural Stem Cells and Progenitorand/or innate immunity to viral infectionsto work on a project aimed at evaluating the consequences of the AGS gene defects in the human Central Nervous Systems (CNS) taking advantage of iPSC-based in vitrodifferentiations. The goal is to elucidate the role of different cell types of the CNS, including microglia, in AGSand to investigate what are the endogenous signals that aberrantly activate the disease-causing antiviral responsesin these cells. We combine molecular virology approaches with state-of-the-art NGS technology and proteomics in the highly relevant context of human iPSC-based in vitro disease models.