Two post-doctoral fellow positions are available, starting February 2024, in the Lab of Prof. Anna Kajaste-Rudnitski at the Department of Biology and Biotechnology of the University of Pavia, Pavia, Italy. About the project The goal of this ERC-funded project is to elucidate molecular mechanisms of nucleic acid sensing and pathogen recognition in clinically relevant targets of gene therapy for the development of innovative cell and gene therapy strategies and to fight infectious and autoimmune diseases. We combine molecular virology approaches with state-of-the-art NGS technologies and proteomics in advanced in vitro and in vivo models. What we look for The candidate must hold a PhD Degree in Biological Sciences, Biotechnology, or related disciplines with skills in molecular and cellular biology, as well as primary human cell culture and manipulation. Experience in iPSC culture and differentiation is a significant plus. Proficient English, independent working capacity, excellent organizational skills and team spirit are required.

We are pleased to announce an opening for Post-Doctoral position in the field of molecular biology and therapeutic applications in breast cancer and melanoma progression. The laboratory (lab) is located at the Molecular Biotechnology Center (MBC), Dept. Mol. Biotechnology and Health Sciences, Via Nizza, 52, Torino. The successful candidate will be supported by a competitive salary (Assegno di ricerca or Fellowship).

We are seeking a highly motivated research scientist with previous training in cell biology and/or biochemistry for a postdoctoral position (24 months) working on "Role of (macro)autophagy in the regulation of turn-over, unconventional secretion and inter-neuronal spreading of neurodegenerative diseases- associated aggregation-prone proteins". The successful candidate will be enrolled on a funded research project aimed at identifying novel genes and signalling pathways regulating the interplay between mammalian autophagy and neurodegenerative diseases. More specifically, the project will require the use of up-to-date molecular and cellular biology techniques, such as confocal and live cell imaging, gene expression and mass spectrometry analyses, siRNA, shRNA and CRISPR/CAS9-based molecular manipulations of target gene expression, functional analyses in cell lines, patients-derived primary cells and ultimately in animal disease models, which will be deployed to analyse the contribution of the autophagic- lysosomal and unconventional secretion pathways to neurodegenerative diseases. Desired skills and experience The successful candidate should have a PhD with a solid background in molecular biology, cell biology and/or biochemistry. Research experience in molecular biology (including molecular cloning, DNA, RNA and protein manipulations) as well as an extensive experience in cell biology and cell imaging techniques are required. Additional experience in isolation and culture of primary cells, mass spectrometry and bioinformatic analyses would be considered advantageous. Interested applicants should submit a letter of application, CV and references (or informal enquiries) to: Maurizio Renna, PhD (maurizio.renna@unina.it)

Applications are invited for a temporary post of a Post-doctoral Research Fellow Level 1 within School of Medicine. Applications are invited from suitably qualified candidates for a full time fixed term position as a post-doctoral researcher working within the laboratory of Dr. Claire Robinson. The successful candidate will investigate the role of the unfolded protein response (UPR) in pancreatic cancer. The position is funded by Breakthrough Cancer Research and is for a fixed term of 24 months Project description

We are pleased to announce a stimulating opportunity for aspiring researchers (from Italy and abroad) in the field of molecular oncology. We offer a predoctoral training program designed to prepare candidates for admission to the PhD course in Molecular Medicine at the University of Torino. Successful candidate(s) will be supported by a salary throughout the beginning of the PhD Course (November 1st, 2023).

A short term post-doctoral position is immediately available in the laboratory of prof. Licio Collavin at the University of Trieste (http://tinyurl.com/collavinlab) The lab is focused on the molecular mechanisms that determine cancer aggressiveness, with a special interest in function and regulation of the tumor suppressor DAB2IP, a Ras-GAP and signaling adaptor that modulates multiple oncogenic pathways. For more information, or to apply, feel free to write directly to prof. Collavin

The goal of our lab at the San Raffaele – Telethon institute for Gene Therapy (SR-TIGET) in Milan is to study the regulation of blood cell emergence during human embryonic development. To this aim, we use our innovative hESCs/hiPSCs platform and combine developmental cell and molecular biology to understand normal and pathological human hematopoietic development, with a particular interest in studying the genetic origins for blood disorders and developing novel strategies for their treatment.

A two-year post-doc position on the project entitled “The lncRNA PHOX2B-AS1 in the pathogenesis and as potential drug target in Congenital Central Hypoventilation Syndrome (CCHS)” founded by the Telethon Foundation, is available at the “Molecular Pharmacology” laboratory (PI Prof. Fornasari), Dept. of Medical Biotechnology and Translational Medicine, University of Milan.

We are looking for a highly motivated and enthusiastic individual to study the process of inflammation. In particular, the selected candidate will investigate the role of intracellular immune receptors in shaping immune responses under physiological and pathological conditions, such as chronic inflammatory diseases. These studies will collectively advance our understanding of inflammatory disorders and improve patients’ care.

Background Gene co-expression networks have been used to define prognostic gene signatures and centrally connected genes as therapeutic targets in cancer. However, most of these studies are purely descriptive, not fully exploiting the wealth of information hidden in the constructed networks to investigate specific biological hypotheses. Moreover, networks have never been compared across breast cancer (BC) subtypes, despite the potential usefulness of such an approach to understand how specific molecular features are established and regulated. Hypothesis We posited that reconstructing BC transcriptional networks could allow us to address biological questions related both to BC in general and to specific BC sub-types. Allowing to formulate testable hypotheses about how biologically/clinically relevant gene expression patterns are established and maintained in specific BC sub-types, such an approach could be exploited to identify and validate potential key regulatory genes, developing them into therapeutic targets. Aims We have implemented a workflow based on the analysis of the METABRIC BC gene expression dataset, which we have validated both based on database analyses and on experimental approaches. We aim at confirming its validity as a tool to dissect molecular pathways linked to BC aggressiveness, particularly basal-like BC for which a targeted treatment is still lacking, identifying key regulatory genes amenable to therapeutic intervention. AIM 1) Discovering how clinically relevant BC gene expression patterns are established by identifying transcriptional regulatory hubs and validating them as therapeutic targets. AIM2 ) Identifying drugs able to target relevant co-expression modules via a drug repositioning approach. AIM 3) Identifying central regulators of specific stromal signatures. AIM 4) demonstrating siRNA-mediated in vivo target ability of identified transcriptional regulators