Two Post-Doctoral Research Fellowships Available at the School of Medicine and Surgery of the University of Milano-Bicocca in the research group led by Emanuele Azzoni, within the framework of two exciting and ambitious projects, respectively funded by WORLDWIDE CANCER RESEARCH (WWCR) and FONDAZIONE CARIPLO/FONDAZIONE TELETHON. Both projects are aimed at understanding the role of inflammatory pathways in the context of juvenile myelomonocytic leukemia (JMML), a type of blood cancer affecting young children, for which new treatments are urgently needed.

Postdoctoral positions are immediately available in the Laboratory of Muscle Stem Cells and Gene Regulation (LMSCGR) at NIAMS of the National Institutes of Health, Bethesda, MD, USA. Ambitious and strongly motivated individuals with a solid background in molecular biology (bioinformatics is desirable but not required) are invited to apply. The main areas of investigations relate to: 1)Intersection of metabolism and epigenetics in the regulation of skeletal muscle stem cell biology 2)Role of chromatin- and histone-modifying protein complexes in embryonic and muscle stem cells

A postdoc position to work on chromosome instability and micronuclei in cancer development is available in the Genome Integrity lab led by Prof. Stefano Santaguida at European Institute of Oncology (IEO, Milano).

We are looking for a postdoctoral researcher to join the Maiuri team at the Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, Italy. Our group studies how cells sense and react to mechano-chemical stimuli coming from the surrounding micro-environment. Particularly, we are interested to investigate how those stimuli impact on the cell nucleus.

We are seeking expressions of interest for a post-doctoral position from highly motivated candidates that would like to join our group at the Department of Biosciences, University of Milan, Italy. The successful candidate will work on a PRIN 2022 funded project, and he/she will employ a combination of molecular, cellular, and in vivo approaches to dissect novel epigenetic events occurring in breast cancer stem cells and related to metastasis formation. The project will involve the use of molecular and cellular biology techniques, including 3D cell cultures and NGS. The optimal candidates would be highly motivated, have a strong background in molecular or cellular biology, experience in transcriptional regulation and cell biology. Candidates holding a PhD degree are welcome to apply but highly motivated candidates at earlier stages of their scientific careers will also be considered. Potential candidates are invited to send a curriculum vitae, a brief statement of research interests and contact information of 2 references to Giuseppina Caretti, giuseppina.caretti@unimi.it.

Two post-doctoral fellow positions are available, starting February 2024, in the Lab of Prof. Anna Kajaste-Rudnitski at the Department of Biology and Biotechnology of the University of Pavia, Pavia, Italy. About the project The goal of this ERC-funded project is to elucidate molecular mechanisms of nucleic acid sensing and pathogen recognition in clinically relevant targets of gene therapy for the development of innovative cell and gene therapy strategies and to fight infectious and autoimmune diseases. We combine molecular virology approaches with state-of-the-art NGS technologies and proteomics in advanced in vitro and in vivo models. What we look for The candidate must hold a PhD Degree in Biological Sciences, Biotechnology, or related disciplines with skills in molecular and cellular biology, as well as primary human cell culture and manipulation. Experience in iPSC culture and differentiation is a significant plus. Proficient English, independent working capacity, excellent organizational skills and team spirit are required.

We are pleased to announce an opening for Post-Doctoral position in the field of molecular biology and therapeutic applications in breast cancer and melanoma progression. The laboratory (lab) is located at the Molecular Biotechnology Center (MBC), Dept. Mol. Biotechnology and Health Sciences, Via Nizza, 52, Torino. The successful candidate will be supported by a competitive salary (Assegno di ricerca or Fellowship).

We are seeking a highly motivated research scientist with previous training in cell biology and/or biochemistry for a postdoctoral position (24 months) working on "Role of (macro)autophagy in the regulation of turn-over, unconventional secretion and inter-neuronal spreading of neurodegenerative diseases- associated aggregation-prone proteins". The successful candidate will be enrolled on a funded research project aimed at identifying novel genes and signalling pathways regulating the interplay between mammalian autophagy and neurodegenerative diseases. More specifically, the project will require the use of up-to-date molecular and cellular biology techniques, such as confocal and live cell imaging, gene expression and mass spectrometry analyses, siRNA, shRNA and CRISPR/CAS9-based molecular manipulations of target gene expression, functional analyses in cell lines, patients-derived primary cells and ultimately in animal disease models, which will be deployed to analyse the contribution of the autophagic- lysosomal and unconventional secretion pathways to neurodegenerative diseases. Desired skills and experience The successful candidate should have a PhD with a solid background in molecular biology, cell biology and/or biochemistry. Research experience in molecular biology (including molecular cloning, DNA, RNA and protein manipulations) as well as an extensive experience in cell biology and cell imaging techniques are required. Additional experience in isolation and culture of primary cells, mass spectrometry and bioinformatic analyses would be considered advantageous. Interested applicants should submit a letter of application, CV and references (or informal enquiries) to: Maurizio Renna, PhD (maurizio.renna@unina.it)

Applications are invited for a temporary post of a Post-doctoral Research Fellow Level 1 within School of Medicine. Applications are invited from suitably qualified candidates for a full time fixed term position as a post-doctoral researcher working within the laboratory of Dr. Claire Robinson. The successful candidate will investigate the role of the unfolded protein response (UPR) in pancreatic cancer. The position is funded by Breakthrough Cancer Research and is for a fixed term of 24 months Project description

We are pleased to announce a stimulating opportunity for aspiring researchers (from Italy and abroad) in the field of molecular oncology. We offer a predoctoral training program designed to prepare candidates for admission to the PhD course in Molecular Medicine at the University of Torino. Successful candidate(s) will be supported by a salary throughout the beginning of the PhD Course (November 1st, 2023).