Research focuses on understanding how nuclear acyl-CoA metabolism influences chromatin remodeling and transcriptional regulation. Mitochondrial enzymes that produce acyl-CoAs, essential metabolites for chromatin modifications and gene activity, have been observed to be present and functional in the nucleus, where they generate metabolic niches that enhance local nuclear acyl-CoA synthesis, thereby impacting gene activity. This project uses omics-based approaches, metabolite tracing, proximity-labeling, and advanced imaging techniques to explore how these nuclear metabolic enzymes regulate gene expression, interact with chromatin factors, and contribute to nuclear organization and function.

A fully funded 3 years post-doctoral position is available in Terzi Lab to explore the role of a renal specific transcription factor in the progression of chronic kidney disease progression. The successful candidate will join a dynamic and collaborative team to work on cutting-edge research that has the potential to uncover new therapeutic strategies.

The LRCB (KU Leuven) is interested in studying RNA metabolism in cancer. In particular, we aim at characterising long non-coding RNAs important for cancer progression. Towards this we apply cutting edge molecular biology and biochemistry techniques coupled to in vivo and ex vivo preclinical studies, with the ultimate goal of identifying promising therapeutic targets. The laboratory hosts also Trace, a state-ofthe- art facility offering a unique collection of >150 well-annotated patient-derived models, belonging to 11 tumour types. KU Leuven is an exciting, interdisciplinary university hosting excellent facilities and research groups and providing extensive opportunities for training.

1-year postdoc position in my lab (vaccarilab.unimi.it) at the Department of Biosciences of the University of Milan. We study lysosomes and autophagy in fly models of rare disease. We use a combination of genetic, imaging and biochemical approaches and quantitative phenotypic assessments.

A Postdoctoral fellow position is available in the laboratory of “Stem cell-based functional genomics of cardiovascular disease” directed by Dr. Valentina Lo Sardo.

The European Institute of Oncology is seeking a bioinformatician in the Laboratory of Endocytosis, Signalling and Cancer, directed by Prof. Pier Paolo Di Fiore. The successful candidate will be involved in cutting-edge cancer research that integrates high-throughput and high-resolution approaches to unravel the mechanisms of carcinogenesis and metastasis. The group is strongly interested in both basic and applied cancer research.

A post-doctoral position is open in the Gabellini laboratory at San Raffaele Scientific Institute to characterize the molecular pathogenesis of acute lymphoblastic leukemia and test novel therapeutic approaches. The project will integrate manipulation of cellular and animal models with genome-wide and functional approaches.

We are seeking two post-docs to join our group and push forward published and unpublished work on the role of mitochondria as transducers of mechanical signals in physiology and disease. We have competitive three-year positions fully funded by AIRC and CARIPARO.

A three-year post-doctoral position funded by a MFAG AIRC is available in the laboratory of Prof. Sirio Dupont and Dr. Patrizia Romani in the Department of Molecular Medicine, University of Padova, to study the link between ferroptosis and aggressive melanoma dissemination through the blood.

Nei carcinomi mammari l’aumento dell’attività metabolica del tumore ha un valore sia prognostico, in quanto individua i tumori a decorso peggiore, sia predittivo, poiché è in grado di predire la risposta a chemioterapia neoadiuvante nei tumori appartenenti al sottotipo Triplo-negativo. Malgrado queste evidenze non esistono, al momento, marcatori metabolici in grado di rivelare i carcinomi mammari caratterizzati da elevata attività metabolica e di correlarli al rischio di recidiva o a trattamenti specifici. Recentemente, nel nostro laboratorio, sono stati identificati alcuni marcatori in grado di correlare con la prognosi delle pazienti e con lo status metabolico del loro tumore. La caratterizzazione proposta, prevede sia uno studio riguardante il loro valore predittivo di ricorrenza all’interno del sottotipo Luminale, sia uno studio molecolare e preclinico sulla loro capacità di predire la sensibilità a trattamenti mirati. Il progetto prevede, inoltre, l’opportunità di lavorare nell’ambito della ricerca oncologica secondo una visione sistemica e interdisciplinare, caratterizzata da nozioni relative a prevenzione e valorizzazione della ricerca nel campo delle biotecnologie.