We are looking for a researcher who will help develop new techniques and assays to integrate stem cell biology, immunology and developmental biology. As a research assistant,you will also provide technical support to the projects of other researchers in the lab as well as help with general lab management. Experimental approaches include cell and molecular biology, flow cytometry and cell sorting as well as in vivo model systems, for which previous experience is required.

The laboratory on Prof. Massimo Santoro (www.massimosantorolab.com) is seeking a PhD student to study the role of mevalonate metabolism and ferroptosis in cancer growth and spreading (Santoro, Cell Metabolism, 2020: Arslanbaeva and Santoro, Redox Biology, 2020). Our team has recently identified a set of novel metabolic enzymes that is crucial for regulation of mevalonate metabolism and ferroptosis (Mugoni et al., Cell 2013, Mugoni et al., Nature Protocols, 2013; Oberkersch et al., 2020 in revision: Tosi et al., 2021 in preparation). Using mouse genetic approaches as well as advanced molecular and microscopic techniques we want to elucidate how lipid signaling and metabolism regulate melanoma survival and progression. Our laboratory has acquired strong experience in biochemistry, genetic, molecular and cellular biology of endothelial and cancer cells and animal models. Mouse animal facility, single cell RNA-seq, STED, multiphoton, light sheet microscopy equipment, and metabolic/proteomic core facilities are available in the laboratory and department. We believe that such studies offer unique opportunities for designing new therapeutic strategies against metastasis and cancer spreading.