The UCD Cancer Data lab are currently looking to recruit computational biology postdocs. We are a supportive and collaborative interdisciplinary research group based in the Conway Institute in University College Dublin. We are broadly interested in understanding how mutations in cancer alter molecular interaction networks and in identifying ways to target these alterations therapeutically. We have a particular interest in identifying genetic interactions in cancer and understanding how they influence tumour genome evolution. You can read more about areas of specific research interest here.
Are you an ambitious MSc or PhD student seeking a challenge at the forefront of genomics, computational biology and RNA therapeutics?
The “Unit of Pathogenesis and Treatment of Immune and Bone Diseases” lab, led by Anna Villa at the San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Milan, Italy is recruiting a talented and motivated research fellow. The project will be focused on the study of ectopic bone marrow niche and optimization of innovative gene correction platform. The research activities of our laboratory are focused on the study of pathological mechanisms of immune and bone diseases and the preclinical evaluation of innovative therapeutic approaches based on gene therapy and novel conditioning regimens. As part of the SR-TIGET, a world-leading Institute in the field of gene and cell therapy for the treatment of human genetic diseases, we benefit from a highly competitive, international and scientifically stimulating environment and offer excellent state-of-the-art facilities and infrastructures, and access to clinically relevant human samples.
Position as Researcher available at the Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo. The position is for a period of 3 years. The candidate will generate and analyze new, cutting-edge high-throughput sequencing data of three-dimensional (3D) genome reorganization during nuclear deformations. The goal is to unravel new mechano-transduction pathways linked to 3D genome reorganization in cancer. The candidate for this position will work on a project funded by the Norwegian Cancer Society. The work will be carried out in a cross-disciplinary collaboration between the research groups of Associate Professor Jonas Paulsen and Prof. Cinzia Progida. Building on bioinformatics software developed in Paulsen research group [Nature Protoc. 2018; Nature Genetics 2019], the data will be used to generate predictive computational models of 3D genome deformation and gene expression changes during different types of nuclear deformations. Imaging techniques, including super-resolution imaging, will be used to validate the models. The Department of Biosciences has access to state-of-the-art infrastructure, including a High-throughput sequencing facility (Norwegian Sequencing Centre), as well as an imaging facility (NorMIC)
We have discovered that cancers increase the production/accumulation of abnormal ncRNA, which activate the RNA sensing pathway in cells of the tumor microenvironment through extracellular vesicles (tEVs), (Biagini et al., submitted). The project, funded by AIRC (www.airc.it/english), aims at characterizing the effects of the RNA sensing pathway in tumors and associated immune cells using cell type specific approaches. We will identify the endogenous RNA species involved in signaling to the RNA sensing pathway, and the biogenesis of these ncRNA cargos in tEVs. We have fully funded post-doc and pre-doc/PhD positions to investigate the roles of the RNA sensing pathway in tumor progression and metastasis formation and identify drugs modulating this process.