Position as Postdoctoral Research Fellow available at the Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo in the research group of Professor Cinzia Progida. No one can be appointed for more than one Postdoctoral Research Fellowship at the University of Oslo. The appointment is a fulltime position and is made for a period of three years (10% of which is devoted to required duties, usually in the form of teaching activities). The candidate for this position will work on a project funded by the Norwegian Cancer Society. In this project, we aim to unravel the role of the endoplasmic reticulum-focal adhesions contact sites in transducing external cues to the nucleus, leading to altered gene expression, and how this is coupled with the development of the cancer cell invasive ability during cancer progression. To achieve this, the project will make use of RNAi screens and advanced imaging techniques such as super-resolution and live imaging. Our group has access to the National imaging platform NorMIC Oslo, with a wide range of state-of-the-art imaging equipment. The Department of Biosciences harbors also an EM-lab, the Norwegian Sequencing Centre (NSC) and Proteomics services. The main purpose of a postdoctoral fellowship is to provide the candidates with enhanced skills to pursue a scientific top position within or beyond academia. To promote a strategic career path, all postdoctoral research fellows are required to submit a professional development plan no later than one month after commencement of the postdoctoral period.
Position as Researcher available at the Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo. The position is for a period of 3 years. The candidate will generate and analyze new, cutting-edge high-throughput sequencing data of three-dimensional (3D) genome reorganization during nuclear deformations. The goal is to unravel new mechano-transduction pathways linked to 3D genome reorganization in cancer. The candidate for this position will work on a project funded by the Norwegian Cancer Society. The work will be carried out in a cross-disciplinary collaboration between the research groups of Associate Professor Jonas Paulsen and Prof. Cinzia Progida. Building on bioinformatics software developed in Paulsen research group [Nature Protoc. 2018; Nature Genetics 2019], the data will be used to generate predictive computational models of 3D genome deformation and gene expression changes during different types of nuclear deformations. Imaging techniques, including super-resolution imaging, will be used to validate the models. The Department of Biosciences has access to state-of-the-art infrastructure, including a High-throughput sequencing facility (Norwegian Sequencing Centre), as well as an imaging facility (NorMIC)
We have discovered that cancers increase the production/accumulation of abnormal ncRNA, which activate the RNA sensing pathway in cells of the tumor microenvironment through extracellular vesicles (tEVs), (Biagini et al., submitted). The project, funded by AIRC (www.airc.it/english), aims at characterizing the effects of the RNA sensing pathway in tumors and associated immune cells using cell type specific approaches. We will identify the endogenous RNA species involved in signaling to the RNA sensing pathway, and the biogenesis of these ncRNA cargos in tEVs. We have fully funded post-doc and pre-doc/PhD positions to investigate the roles of the RNA sensing pathway in tumor progression and metastasis formation and identify drugs modulating this process.