We have discovered that cancers increase the production/accumulation of abnormal ncRNA, which activate the RNA sensing pathway in cells of the tumor microenvironment through extracellular vesicles (tEVs), (Biagini et al., submitted). The project, funded by AIRC (www.airc.it/english), aims at characterizing the effects of the RNA sensing pathway in tumors and associated immune cells using cell type specific approaches. We will identify the endogenous RNA species involved in signaling to the RNA sensing pathway, and the biogenesis of these ncRNA cargos in tEVs. We have fully funded post-doc and pre-doc/PhD positions to investigate the roles of the RNA sensing pathway in tumor progression and metastasis formation and identify drugs modulating this process.

The Laboratory of Computational Modeling at the University of Trento (CIBIO Department, PI Luca Marchetti), in collaboration with Fondazione COSBI, is seeking for: 1. a senior post-doc mathematical modeler, with previous consolidated experience in quantitative systems pharmacology (QSP) projects, with preferential knowledge in the area of mRNA-based products 2. a junior post-doc mathematical modeler, with experience in the area of mathematical modeling of biological processes to foster a joint investigation effort in mathematical QSP modeling of mRNA-based products, specifically vaccines and monoclonal antibodies (mAb), in the context of the International Wellcome Leap project “R3: RNA Readiness and Response”.

The Laboratory of Computational Modeling at the University of Trento (CIBIO Department, PI Luca Marchetti), in collaboration with Fondazione COSBI, is seeking for: 1. a senior post-doc mathematical modeler, with previous consolidated experience in quantitative systems pharmacology (QSP) projects, with preferential knowledge in the area of mRNA-based products

I bandi di concorso ai premi e alle borse di studio 2022 sono pubblicati sul sito dell'Accademia Nazionale dei Lincei al link: https://www.lincei.it/it/bandi-premi-borse