We have discovered that cancers increase the production/accumulation of abnormal ncRNA, which activate the RNA sensing pathway in cells of the tumor microenvironment through extracellular vesicles (tEVs), (Biagini et al., submitted). The project, funded by AIRC (www.airc.it/english), aims at characterizing the effects of the RNA sensing pathway in tumors and associated immune cells using cell type specific approaches. We will identify the endogenous RNA species involved in signaling to the RNA sensing pathway, and the biogenesis of these ncRNA cargos in tEVs. We have fully funded post-doc and pre-doc/PhD positions to investigate the roles of the RNA sensing pathway in tumor progression and metastasis formation and identify drugs modulating this process.

The Laboratory of Computational Modeling at the University of Trento (CIBIO Department, PI Luca Marchetti), in collaboration with Fondazione COSBI, is seeking for: 1. a senior post-doc mathematical modeler, with previous consolidated experience in quantitative systems pharmacology (QSP) projects, with preferential knowledge in the area of mRNA-based products 2. a junior post-doc mathematical modeler, with experience in the area of mathematical modeling of biological processes to foster a joint investigation effort in mathematical QSP modeling of mRNA-based products, specifically vaccines and monoclonal antibodies (mAb), in the context of the International Wellcome Leap project “R3: RNA Readiness and Response”.

The Laboratory of Computational Modeling at the University of Trento (CIBIO Department, PI Luca Marchetti), in collaboration with Fondazione COSBI, is seeking for: 1. a senior post-doc mathematical modeler, with previous consolidated experience in quantitative systems pharmacology (QSP) projects, with preferential knowledge in the area of mRNA-based products

Position as Researcher available at the Department of Biosciences, University of Oslo in the research group of Professor Cinzia Progida. The position is for a period of 16 months. The candidate for this position will work on a project funded by the Norwegian Cancer Society. The goal of this project is to identify and characterize molecules and pathways involved in lysosome transformation in cancer cells, and how this is coupled with the development of the cancer cell migratory and invasive ability. Our group has access to the National imaging platform NorMIC Oslo. The Department of Biosciences harbors also an EM-lab, the Norwegian Sequencing Centre (NSC) and Proteomics services. The work includes collaboration with national and international groups and the candidate will have the possibility to spend a short visiting period in the lab of prof. Roberto Zoncu at the University of California, Berkeley.

The focus of our lab is to unravel the molecular basis of vascular and tumor biological processes using functional genomic approaches and, if possible, try to use these genetic insights to develop novel therapeutic strategies, and translate them into novel medicine.