The successful candidate (H/F) will join Angela Taddei's team and work in close collaboration with Valérie Borde's team, both belonging to the Institut Curie Research Center and affiliated to the Nuclear Dynamics and Dynamics of Genetic Information departments respectively.

The Gulbenkian Institute of Molecular Medicine (GIMM) is recruiting three outstanding Group Leaders to join our growing faculty. Established in 2024 through the merger of the Gulbenkian Institute for Science (IGC) and the Institute of Molecular Medicine (iMM), GIMM is a leading Portuguese life sciences research institute dedicated to fundamental and biomedical research. Our mission is to drive transformative discoveries that advance knowledge, human health and global well-being.

Research focuses on understanding how nuclear acyl-CoA metabolism influences chromatin remodeling and transcriptional regulation. Mitochondrial enzymes that produce acyl-CoAs, essential metabolites for chromatin modifications and gene activity, have been observed to be present and functional in the nucleus, where they generate metabolic niches that enhance local nuclear acyl-CoA synthesis, thereby impacting gene activity. This project uses omics-based approaches, metabolite tracing, proximity-labeling, and advanced imaging techniques to explore how these nuclear metabolic enzymes regulate gene expression, interact with chromatin factors, and contribute to nuclear organization and function.

We are looking for 3 highly motivated PhD students interested in how Metabolism affects Genome Regulation and Cell Identity

MemBioMed offers cutting-edge training on biomembranes, covering key topics such as lipids and membrane proteins, and prepares the next generation of scientists, entrepreneurs, and leaders to explore the complex behavior of cellular membranes and unlock their therapeutic potential.