Research focuses on understanding how nuclear acyl-CoA metabolism influences chromatin remodeling and transcriptional regulation. Mitochondrial enzymes that produce acyl-CoAs, essential metabolites for chromatin modifications and gene activity, have been observed to be present and functional in the nucleus, where they generate metabolic niches that enhance local nuclear acyl-CoA synthesis, thereby impacting gene activity. This project uses omics-based approaches, metabolite tracing, proximity-labeling, and advanced imaging techniques to explore how these nuclear metabolic enzymes regulate gene expression, interact with chromatin factors, and contribute to nuclear organization and function.

We are looking for 3 highly motivated PhD students interested in how Metabolism affects Genome Regulation and Cell Identity

MemBioMed offers cutting-edge training on biomembranes, covering key topics such as lipids and membrane proteins, and prepares the next generation of scientists, entrepreneurs, and leaders to explore the complex behavior of cellular membranes and unlock their therapeutic potential.

A fully funded 3 years post-doctoral position is available in Terzi Lab to explore the role of a renal specific transcription factor in the progression of chronic kidney disease progression. The successful candidate will join a dynamic and collaborative team to work on cutting-edge research that has the potential to uncover new therapeutic strategies.

The LRCB (KU Leuven) is interested in studying RNA metabolism in cancer. In particular, we aim at characterising long non-coding RNAs important for cancer progression. Towards this we apply cutting edge molecular biology and biochemistry techniques coupled to in vivo and ex vivo preclinical studies, with the ultimate goal of identifying promising therapeutic targets. The laboratory hosts also Trace, a state-ofthe- art facility offering a unique collection of >150 well-annotated patient-derived models, belonging to 11 tumour types. KU Leuven is an exciting, interdisciplinary university hosting excellent facilities and research groups and providing extensive opportunities for training.