A post-doctoral position is available in Stefan Schoeftner’s laboratory in the Department of Life Sciences at the University of Trieste (Italy).Research in the Schoeftner laboratory is focusing on non-coding RNA biology, genomic instability and the development of patient derived tumor organoid models.

Position as Postdoctoral Research Fellow available at the Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo in the research group of Professor Cinzia Progida. No one can be appointed for more than one Postdoctoral Research Fellowship at the University of Oslo. The appointment is a fulltime position and is made for a period of three years (10% of which is devoted to required duties, usually in the form of teaching activities). The candidate for this position will work on a project funded by the Norwegian Cancer Society. In this project, we aim to unravel the role of the endoplasmic reticulum-focal adhesions contact sites in transducing external cues to the nucleus, leading to altered gene expression, and how this is coupled with the development of the cancer cell invasive ability during cancer progression. To achieve this, the project will make use of RNAi screens and advanced imaging techniques such as super-resolution and live imaging. Our group has access to the National imaging platform NorMIC Oslo, with a wide range of state-of-the-art imaging equipment. The Department of Biosciences harbors also an EM-lab, the Norwegian Sequencing Centre (NSC) and Proteomics services. The main purpose of a postdoctoral fellowship is to provide the candidates with enhanced skills to pursue a scientific top position within or beyond academia. To promote a strategic career path, all postdoctoral research fellows are required to submit a professional development plan no later than one month after commencement of the postdoctoral period.

Position as Researcher available at the Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo. The position is for a period of 3 years. The candidate will generate and analyze new, cutting-edge high-throughput sequencing data of three-dimensional (3D) genome reorganization during nuclear deformations. The goal is to unravel new mechano-transduction pathways linked to 3D genome reorganization in cancer. The candidate for this position will work on a project funded by the Norwegian Cancer Society. The work will be carried out in a cross-disciplinary collaboration between the research groups of Associate Professor Jonas Paulsen and Prof. Cinzia Progida. Building on bioinformatics software developed in Paulsen research group [Nature Protoc. 2018; Nature Genetics 2019], the data will be used to generate predictive computational models of 3D genome deformation and gene expression changes during different types of nuclear deformations. Imaging techniques, including super-resolution imaging, will be used to validate the models. The Department of Biosciences has access to state-of-the-art infrastructure, including a High-throughput sequencing facility (Norwegian Sequencing Centre), as well as an imaging facility (NorMIC)

We have discovered that cancers increase the production/accumulation of abnormal ncRNA, which activate the RNA sensing pathway in cells of the tumor microenvironment through extracellular vesicles (tEVs), (Biagini et al., submitted). The project, funded by AIRC (www.airc.it/english), aims at characterizing the effects of the RNA sensing pathway in tumors and associated immune cells using cell type specific approaches. We will identify the endogenous RNA species involved in signaling to the RNA sensing pathway, and the biogenesis of these ncRNA cargos in tEVs. We have fully funded post-doc and pre-doc/PhD positions to investigate the roles of the RNA sensing pathway in tumor progression and metastasis formation and identify drugs modulating this process.

The Laboratory of Computational Modeling at the University of Trento (CIBIO Department, PI Luca Marchetti), in collaboration with Fondazione COSBI, is seeking for: 1. a senior post-doc mathematical modeler, with previous consolidated experience in quantitative systems pharmacology (QSP) projects, with preferential knowledge in the area of mRNA-based products 2. a junior post-doc mathematical modeler, with experience in the area of mathematical modeling of biological processes to foster a joint investigation effort in mathematical QSP modeling of mRNA-based products, specifically vaccines and monoclonal antibodies (mAb), in the context of the International Wellcome Leap project “R3: RNA Readiness and Response”.

The Laboratory of Computational Modeling at the University of Trento (CIBIO Department, PI Luca Marchetti), in collaboration with Fondazione COSBI, is seeking for: 1. a senior post-doc mathematical modeler, with previous consolidated experience in quantitative systems pharmacology (QSP) projects, with preferential knowledge in the area of mRNA-based products

Position as Researcher available at the Department of Biosciences, University of Oslo in the research group of Professor Cinzia Progida. The position is for a period of 16 months. The candidate for this position will work on a project funded by the Norwegian Cancer Society. The goal of this project is to identify and characterize molecules and pathways involved in lysosome transformation in cancer cells, and how this is coupled with the development of the cancer cell migratory and invasive ability. Our group has access to the National imaging platform NorMIC Oslo. The Department of Biosciences harbors also an EM-lab, the Norwegian Sequencing Centre (NSC) and Proteomics services. The work includes collaboration with national and international groups and the candidate will have the possibility to spend a short visiting period in the lab of prof. Roberto Zoncu at the University of California, Berkeley.

The focus of our lab is to unravel the molecular basis of vascular and tumor biological processes using functional genomic approaches and, if possible, try to use these genetic insights to develop novel therapeutic strategies, and translate them into novel medicine.

The laboratory of Prof. Massimo M. Santoro at University of Padua is seeking a post-doctoral fellow to study the role of metabolism in cancer growth and spreading. Our lab has recently identified a set of novel metabolic enzymes that are crucial for the regulation of lipid metabolism and antioxidant response (Mugoni et al., Cell, Mugoni et al., Nature Protocols, Santoro, Cell Metabolism; Arslanbaeva and Santoro, Redox Biology, Facchinello et al.,Nature Metabolism, in press). Using mouse genetic approaches as well as advanced molecular and metabolic techniques we want to elucidate how lipids and metabolism regulate cancer survival and progression. Our laboratory has acquired strong experience in the field of metabolism, genetic, molecular and cellular biology working with cells and animal models.

The Research Strategy and Communication Office supports the SR-Tiget Director in a variety of strategic and operational activities, including strategic planning, reporting, internal and external communication. The Research Strategy and Communication Officer, reporting to the Research Strategy and Communication Manager, will provide highly organized and efficient support to the Office operations with a specific focus on the production of scientific content and documents, and organization of scientific events.