We, the team of Marcus Buschbeck at the headquarters of the Josep Carreras Leukaemia Research Institute (Badalona, Barcelona, Spain), are looking for a motivated researcher who is interested in developing a research line in the emerging field of metabolic regulation of the genome. Focusing on leukaemia, the postdoc will take an active role in the recently funded MSCA doctoral network NUCLEAR that we are coordinating on the topic. The postdoc will lead a small team including a PhD student and tightly collaborate with other members of the lab, the institute and the NUCLEAR network.

Traditionally, metabolism was viewed as consequence of cell identity, however in the last decade there has been increasing evidence that metabolism plays an active role in cell-fate decisions. Like all biochemical reactions, chromatin regulatory mechanisms are sensitive and influenced by the metabolism in their immediate environment. Cells use this metabolic–chromatin regulation to adapt to environmental cues and changes in nutrient availability. Moreover, there is genetic and epidemiologic evidence that failure in the cellular capacity to adapt to nutritional changes leads to cancer or other diseases. Embedded in the NUCLEAR network, we consider two major aspects of how nuclear metabolism regulates genome functions. First, we will evaluate whether leukemia-associated metabolic changes impact chromatin and disease-relevant gene regulation. Second, we will assess which metabolic enzymes are located in the nucleus of leukemia cells and if they contribute to chromatin regulation. The postdoc will dissect one of these aspects in the context of acute myeloid leukaemia or another haematological disease.

For more info about the lab please check out our website: https://www.buschbecklab.org

What we need:

a) A high level of motivation and interest.
b) High-level of collaborative and communicative skills.
c) Relevant expertise in chromatin biology or blood cancers.
d) Technical expertise in cell culture methods, molecular biology and biochemistry,
e) Competitive CV with a track record of publications.
f) PhD title.
g) Meeting the MSCA mobility criteria of not having lived in Spain for more than 12 months during the last 3 years.
h) 0-7 years of postdoc experience.
i) Good level of English speaking and writing skills (required). Spanish (helpful).

What we offer:

a) Incorporation in a multinational and highly collaborative team.
b) An innovative and interdisciplinary research project.
c) Mixed basic and clinical research environment of the Josep Carreras Leukaemia Research Institute.
d) The international network of the Buschbeck lab.
e) The stimulating environment of the Barcelona metropolitan area.
f) Three-year contract with an attractive salary.                                                                                                                                                                                                                               g) Preferential start date: Any time after February 2023.                                                                  

How to apply:

The position will require a successful application to the in-house MSCA postdoctoral program CarrerasLeaders. (https://carrerasleaders.eu). The application deadline is end of October and candidates will be selected through a competitive selection process. To allow for sufficient time of preparation, interested candidates are encouraged to get into contact with Marcus by email (mbuschbeck@carrerasresearch) before September 27.

About the institute:

The Josep Carreras Leukaemia Research Institute (IJC) is a non-profit research institute based in Barcelona dedicated to advancing the understanding of leukemia and related disorders, in collaboration with the University of Barcelona and the Autonomous University of Barcelona. The IJC has laboratories in 5 clinical campuses: i) Hospital Clínic, ii) Hospital de Sant Pau and iii) Hospital Germans Trias Pujol iv) Hospital del Mar and v) Hospital Josep Trueta Girona. IJC serves as a collaborative center for basic researchers and physicians to work together on fundamental clinical and biological aspects of leukemia. The IJC offers an excellent work environment based on a multidisciplinary fusion of state-of-the-art ideas and facilities.
Our mission is to carry out research into the basic, epidemiological, preventive, clinical and translational aspects of leukemia and other hematologic malignancies.
The vision of the Josep Carreras Leukaemia Research Institute is that research will identify new therapeutic targets and enable us to develop more precise and less aggressive treatments. We aspire to understand the origin and development of leukemias and other malignant hematological pathologies to be able to prevent them. We will work for a future in which all leukemias will be curable. For further information, please, visit our webpage: http://www.carrerasresearch.org/en.
The European Commission awarded the IJC the HR Excellence seal (HRS4R) in July 2019. The HRS4R has the main objective of ensuring that research centres of excellence implement and respect the requirements of the European Charter for Researchers and the Code of Conduct for hiring researchers within their human resources policies.
This EC initiative aims to promote training, professional development, and mobility for all European scientists. The IJC supports these values and principles, which will not only serve to strengthen its internal policies but will actively stimulate excellent research and firmly situate the organization as an institution with a stimulating working environment that favours the development of its scientists. IJC is an equal opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, national origin, disability, and other legally protected characteristics.