The Epithelial Carcinogenesis Group at the Spanish National Cancer Research Centre-CNIO (Madrid, Spain) has openings for postdoctoral positions in three exciting projects, as outlined below. The profile of the candidates we are searching is outlined below. CNIO is an international center with excellent core facilities, a very collaborative atmosphere, and a great research environment. We are looking for highly motivated postdocs who will be involved in ongoing projects:

- How does asthma protect from pancreatic cancer development? we will use genetic mouse models to identify the immune mechanisms involved this highly interesting project that links epidemiological observations in patients with mechanistic studies in mice. The candidate should have a strong background in immunology and experience with mouse models of disease.

- ER stress and inflammation: do they cooperate to promote pancreatic cancer initiation? we will use new genetic mouse models developed in the lab to unravel the relationship between these processes. The knowledge acquired will be applied to develop strategies for precision prevention of pancreatic cancer.

- Is the smooth muscle layer a barrier for the progression of bladder cancer? we are addressing this question using a variety of strategies, in vitro and in vivo, to identify the cross-talk between tumor cells and smooth muscle cells. The candidate should preferably have a background in tumor cell biology and the tumor microenvironment.

Selected publications
- Cobo I, Paliwal S,* Bodas C,* et al. NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation. Nat Comm 2023; 14(1):3761.
- de Andrés MP, Jackson R, Felipe I, et al. GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma. Gut 2023; 72:535-548.
- Richart L,* Lapi E,* Pancaldi V, et al. STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cells. Nucl Acids Res 2021; 49:11005- 11021.
- Santos C, Lapi E, Alvaro-Espinosa L, et al. Urothelial organoids originating from Cd49f-high mouse stem cells display Notch-dependent differentiation capacity. Nat Comm 2019; 10(1):4407.
- Cobo I, Martinelli P, Flández M, et al. Transcriptional regulation by NR5A2 links cell differentiation and inflammation in the pancreas. Nature 2018; 554:533-537.