BRIC wishes to recruit 1-2 strongly motivated scientist(s) at Associate Professor or Professor level for an independent research group leader position. We are seeking excellent candidates with ambitious research visions within the broad area of biomedical research and a drive to contribute to a diverse and inspiring research environment. BRIC is an international center of excellence with the mission to perform cutting-edge basic and translational biomedical research in an open environment that fosters interdisciplinarity and collaboration. Active research areas include many aspects of cancer biology, stem cell biology and neurobiology. The center is part of the Faculty of Health and Medical Sciences, University of Copenhagen.

I bandi sono rivolti a candidati/e con alta qualificazione ed esperienza scientifica e managerial negli ambiti di pertinenza.

A postdoc position to work on chromosome instability and micronuclei in cancer development is available in the Genome Integrity lab led by Prof. Stefano Santaguida at European Institute of Oncology (IEO, Milano).

Defilippi’s lab will offer to the applicant all the conditions to carry out her/his work, with innovative techniques in a centre which benefit of the facilities required to carry on the proposed research, including fully equipped cell culture, microscope and animal facility.

Two SNSF-funded PhD student positions in the group “Mechanisms of Inherited Kidney Disorders” co-led by Prof. Olivier Devuyst and Dr. Alessandro Luciani is located at the Institute of Physiology, at the University of Zurich in Switzerland. Project: Unlocking mechanisms and therapeutic paradigms for rare inherited diseases Inherited defects in lysosome-residing proteins can lead to proximal tubulopathy and kidney disease. Recessive mutations in CTNS, the gene encoding cystinosin/CTNS, cause cystinosis, a lysosomal storage disease characterized by early and severe dysfunction of kidney tubular epithelial cells, progressing towards chronic kidney disease (CKD) and life-threatening complications. Using cystinosis as a paradigm of lysosome dysfunction causing proximal tubulopathy and kidney disease, the project aims to dissect the biological roles of lysosomes in the context of homeostasis, kidney disease, and therapeutic discovery. The applicants will combine preclinical disease models (mouse, rat, and zebrafish), physiologically-relevant cell systems, cell-and lysosome-based function assays, and disease-relevant screening technologies (i) to decipher how the lysosome direct cell fate determination in the kidney tubule epithelium; and to (ii) dissect factors and mechanisms of lysosomal reformation and their roles in normal and diseased cells. By synergizing prior knowledge-based approaches and artificial intelligence (AI)-powered engine with a cross-species screening and validation workflow, the applicant will rank and prioritize actionable drug targets addressing dysregulated homeostasis in cystinosis. Our ultimate goal is to expedite the effective translation of therapeutic agents from preclinical systems to clinical benefits for individuals with cystinosis and other lysosome-related diseases.