Defilippi’s lab will offer to the applicant all the conditions to carry out her/his work, with innovative techniques in a centre which benefit of the facilities required to carry on the proposed research, including fully equipped cell culture, microscope and animal facility.

Two research fellowships application will be opened in early December at the Institute of Molecular Biology and Pathology (IBPM-CNR) to work on a PNRR project entitled “Neurofibromatosis type 1 (NF1) across lifespan: an interdisciplinary model of care from epigenetic to innovative therapeutic approaches”, under the supervision of Dr Cinzia Rinaldo. The research project will be focused on cellular model systems that recapitulate human NF progression to investigate the influence of the microenvironment and the impact of antioxidant compounds -1. position for 12 months (1 year of post-graduate research activity is required). -2. Postdoctoral position of 15 months (students whose final PhD thesis exam is set for the first months of 2024 may apply)

A Postdoctoral fellow position is open to join the team of Dr. Valentina Cianfanelli, at the Department of Science – appointed as Department of Excellence 2018-2022 and 2022-2027 by the Italian Ministry of University and Research - of University Roma TRE

Two SNSF-funded PhD student positions in the group “Mechanisms of Inherited Kidney Disorders” co-led by Prof. Olivier Devuyst and Dr. Alessandro Luciani is located at the Institute of Physiology, at the University of Zurich in Switzerland. Project: Unlocking mechanisms and therapeutic paradigms for rare inherited diseases Inherited defects in lysosome-residing proteins can lead to proximal tubulopathy and kidney disease. Recessive mutations in CTNS, the gene encoding cystinosin/CTNS, cause cystinosis, a lysosomal storage disease characterized by early and severe dysfunction of kidney tubular epithelial cells, progressing towards chronic kidney disease (CKD) and life-threatening complications. Using cystinosis as a paradigm of lysosome dysfunction causing proximal tubulopathy and kidney disease, the project aims to dissect the biological roles of lysosomes in the context of homeostasis, kidney disease, and therapeutic discovery. The applicants will combine preclinical disease models (mouse, rat, and zebrafish), physiologically-relevant cell systems, cell-and lysosome-based function assays, and disease-relevant screening technologies (i) to decipher how the lysosome direct cell fate determination in the kidney tubule epithelium; and to (ii) dissect factors and mechanisms of lysosomal reformation and their roles in normal and diseased cells. By synergizing prior knowledge-based approaches and artificial intelligence (AI)-powered engine with a cross-species screening and validation workflow, the applicant will rank and prioritize actionable drug targets addressing dysregulated homeostasis in cystinosis. Our ultimate goal is to expedite the effective translation of therapeutic agents from preclinical systems to clinical benefits for individuals with cystinosis and other lysosome-related diseases.

We are looking for a postdoctoral researcher to join the Maiuri team at the Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, Italy. Our group studies how cells sense and react to mechano-chemical stimuli coming from the surrounding micro-environment. Particularly, we are interested to investigate how those stimuli impact on the cell nucleus.