The postdoc position and the researcher position are available at the Department of Biosciences, University of Oslo Norway and funded by the Norwegian Research Council and the Norwegian Cancer Society. Project "The intracellular pathway for MHC Class II antigen presentation". The researcher and the postdoc will work in the group of prof. Oddmund Bakke at the Department of Biosciences, University of Oslo and part time at NKI, the Dutch Cancer Institute in Amsterdam.  

The positions are for two years, but a one-year prolongation is possible. Within the framework of the position duties may be assigned. In regards to the post doctoral position, no one can be appointed for more than one fixed-term period at the same institution.

Job Description
The project focuses primarily on unraveling the function of the endocytic pathway toward antigen loading using biophysical techniques, molecular biological techniques, biochemistry, imaging (e.g. live imaging) and molecular/imaging/biochemical screens in cell culture systems and cells from knock out/knock in mice. The project will focus on unraveling the pathway towards MHC II antigen loading, in particular for the molecules that associate with the transport to and from this compartment in immune cells, both in cell lines and in human dendritic cells (See e.g. Neefjes et al., 2011, Nature immunology and publications by the supervisors (Medline, in particular Oddmund Bakke and Jacques Neefjes). We also work, together with a clinical group, and we have patented a vaccine for immunotherapy by improving loading of the MHC molecules, both MHC class I and class II. The Bakke group is a member of a CoE, Centre for Immune Regulation and prof Oddmund Bakke is also the head of the National imaging platform NorMIC Oslo, with a wide range of imaging equipment, including equipment at the Oslo University hospital, a node headed by prof Harald Stenmark.

The work will include collaboration with national and international groups in particular Prof. Jacques Neefjes at the Dutch Cancer Centre, NKI in Amsterdam and with the Preben Morth Group who is a part of the Centre for Molecular Medicine Norway, home page.

Qualifications
The Faculty of Mathematics and Natural Sciences has a strategic ambition of being a leading research faculty. Candidates for these fellowships will be selected in accordance with this, and expected to be in the upper segment of their class with respect to academic credentials.

The candidates must have a PhD or other corresponding education equivalent to a Norwegian doctoral degree in molecular biology, cell biology, biophysics or biochemistry.

We are seeking highly motivated and skilled researchers with broad and extensive experience within one or more of the following areas: advanced imaging, molecular biology, cellular immunology, cell biology, biochemistry, and protein chemistry. Prior experience with intracellular membrane/protein traffic and library screening will be considered a strong advantage. One of the positions will preferentially need extensive experience with advanced cellular imaging and membrane trafficking whereas one will be more focused towards cell biology/intracellular membrane/organelle biogenesis and transport and immunological techniques.

The main purpose of post-doctoral research fellowships is to qualify researchers for work in top academic positions within their disciplines.                

Please also refer to the regulations pertaining to the conditions of employment for post-doctoral fellowship positions.

A good command of English is required.

Salary:

Position code 1352 for post doctoral research fellow, Pay Grade: 57 – 65  (NOK 482 800 – 559 600 per year, depending on qualifications and seniority).

Position code 1109 for researcher, Pay Grade: 57 – 65  (NOK 482 800 – 559 600 per year, depending on qualifications and seniority).

The application must include:

• Application letter, please indicate on your application letter which position you are applying for.
• CV (summarizing education, positions, pedagogical experience, administrative experience and other qualifying activity)
• Copies of educational certificates, transcript of records and letters of recommendation
• Documentation of English proficiency
• A complete list of publications and all academic works that the applicant wishes to be considered by the evaluation committee
• Names and contact details of 2-3 references (name, relation to candidate, e-mail and telephone number)

Please remember that all documents should be in English or a Scandinavian language.

In accordance with the University of Oslo’s equal opportunities policy, we invite applications from all interested individuals regardless of gender or ethnicity.

For detailed information please visit the Institution's web page.