Research focuses on understanding how nuclear acyl-CoA metabolism influences chromatin remodeling and transcriptional regulation. Mitochondrial enzymes that produce acyl-CoAs, essential metabolites for chromatin modifications and gene activity, have been observed to be present and functional in the nucleus, where they generate metabolic niches that enhance local nuclear acyl-CoA synthesis, thereby impacting gene activity. This project uses omics-based approaches, metabolite tracing, proximity-labeling, and advanced imaging techniques to explore how these nuclear metabolic enzymes regulate gene expression, interact with chromatin factors, and contribute to nuclear organization and function.

We are looking for 3 highly motivated PhD students interested in how Metabolism affects Genome Regulation and Cell Identity

Un appello per il futuro dell’Italia: sostenere la ricerca scientifica di Antonio Musarò, Elisabetta Cerbai, Michele Simonato