PhD positions are available in the course of Medical-Surgery BioTechnologies and Translational Medicine in the lab of prof. Francesca Gioia Klinger, at University of Rome Tor Vergata, Department of Biomedicine and Prevention, Section of Histology and Embryology. The research lab focus mainly on advanced techniques to protect and preserve the ovarian reserve in human and in mice models. In line with this, the research concentrate on the discovery of new molecules to be used as fertoprotective agents and the use of mesenchymal stem cells and their released factors to improve and preserve the ovarian environment

The call for applications is open for the PhD in Molecular Biomedicine jointly offered by the Department of Life Sciences of the University of Trieste and the International Centre for Genetic Engineering and Biotechnology (ICGEB) For info please refer to the Admission section of this website where you will find links to the official announcement and info for the application the available projects Deadline June 7, 2021 @ 1 PM CE

This new project is focusing on new regulatory mechanisms of metabolism and their relevance for cancer metastasis, funded by a Worldwide Cancer Research grant. The current research of the lab is focused on mechanotransduction and how this regulates signaling and metabolism.

Aberrant sensing of nucleic acids originating from the expression of endogenous retroviral elements or accumulating DNA damage and consequent increase in type I IFN levels have been suggested to be a primary driver of pathogenesis of the Aicardi-Goutières Syndrome (AGS), a genetic Leukodystrophy that mainly affects the brain, immune system and skin. Nevertheless, the precise molecular mechanisms triggering the disease remain elusive. On these premises, we arerecruiting a post-doctoral fellow with strong experience in iPSC-based differentiation of Neural Stem Cells and Progenitorand/or innate immunity to viral infectionsto work on a project aimed at evaluating the consequences of the AGS gene defects in the human Central Nervous Systems (CNS) taking advantage of iPSC-based in vitrodifferentiations. The goal is to elucidate the role of different cell types of the CNS, including microglia, in AGSand to investigate what are the endogenous signals that aberrantly activate the disease-causing antiviral responsesin these cells. We combine molecular virology approaches with state-of-the-art NGS technology and proteomics in the highly relevant context of human iPSC-based in vitro disease models.

We are looking for a researcher who will help develop new techniques and assays to integrate stem cell biology, immunology and developmental biology. As a research assistant,you will also provide technical support to the projects of other researchers in the lab as well as help with general lab management. Experimental approaches include cell and molecular biology, flow cytometry and cell sorting as well as in vivo model systems, for which previous experience is required.