Avviso di selezione n° 5/AR/2021-CIR-CNRBiOmics-IBIOM-BA per il conferimento di 1 assegno di ricerca
The aim of this project is to clarify the functional and structural relationships between respiratory complexes I and III to understand whether their supramolecular organization in supercomplexes can mitigate the effect of deleterious mutations in cytochrome b,one of the catalytic core subunits of complex III. To this purpose, biochemical approaches will be applied in human and bacterial cellular models carrying mutations in cytochrome b to analyze the structural stability and enzymatic activity of complex III in its isolated form or in assembled supercomplex I+III. The biochemical approaches will be associated with molecular dynamics simulations of supercomplex I+III by modeling wild type and mutated cytochrome b to obtain information on critical interactions between the two complexes for supercomplexes stability. From this project, we expect to obtain new knowledge on the structural and physiological relevance of supercomplexes healthy and pathological conditions.
PhD positions are available in the course of Medical-Surgery BioTechnologies and Translational Medicine in the lab of prof. Francesca Gioia Klinger, at University of Rome Tor Vergata, Department of Biomedicine and Prevention, Section of Histology and Embryology. The research lab focus mainly on advanced techniques to protect and preserve the ovarian reserve in human and in mice models. In line with this, the research concentrate on the discovery of new molecules to be used as fertoprotective agents and the use of mesenchymal stem cells and their released factors to improve and preserve the ovarian environment
The call for applications is open for the PhD in Molecular Biomedicine jointly offered by the Department of Life Sciences of the University of Trieste and the International Centre for Genetic Engineering and Biotechnology (ICGEB) For info please refer to the Admission section of this website where you will find links to the official announcement and info for the application the available projects Deadline June 7, 2021 @ 1 PM CE
This new project is focusing on new regulatory mechanisms of metabolism and their relevance for cancer metastasis, funded by a Worldwide Cancer Research grant. The current research of the lab is focused on mechanotransduction and how this regulates signaling and metabolism.