The laboratory on Prof. Massimo Santoro (www.massimosantorolab.com) is seeking a PhD student to study the role of mevalonate metabolism and ferroptosis in cancer growth and spreading (Santoro, Cell Metabolism, 2020: Arslanbaeva and Santoro, Redox Biology, 2020). Our team has recently identified a set of novel metabolic enzymes that is crucial for regulation of mevalonate metabolism and ferroptosis (Mugoni et al., Cell 2013, Mugoni et al., Nature Protocols, 2013; Oberkersch et al., 2020 in revision: Tosi et al., 2021 in preparation). Using mouse genetic approaches as well as advanced molecular and microscopic techniques we want to elucidate how lipid signaling and metabolism regulate melanoma survival and progression. Our laboratory has acquired strong experience in biochemistry, genetic, molecular and cellular biology of endothelial and cancer cells and animal models. Mouse animal facility, single cell RNA-seq, STED, multiphoton, light sheet microscopy equipment, and metabolic/proteomic core facilities are available in the laboratory and department. We believe that such studies offer unique opportunities for designing new therapeutic strategies against metastasis and cancer spreading.

The focus of the lab(www.donatilab.org) is to understand how transcriptional and epigenetic mechanisms control cell plasticity. This is achieved through the combination of bulk RNA-Seq, single cell RNA-Seq, ChIP-Seq, functional genomics such as pooled shRNA screening, histology and advanced genetic approaches such as lineage tracing in vivo experiments

Applications are invited for postdoctoral research scientists in the area of quantitative molecular and cellular biology, cellular biochemistry and cancer cell biology. The successful candidate will work in close collaboration with a systems biologist to develop and validate a quantitative ODE model of epidermal growth factor receptor (EGFR) activation and trafficking in physiology and cancer. The project is a collaborative effort between the Istituto Europeo di Oncologia (IEO) in Milan, Italy and The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI) in Rovereto (TN), Italy.

A post-doctoral position is available in the laboratory of Dr. Sirio Dupont in the Department of Molecular Medicine of the University of Padova to study new regulatory mechanisms of metabolism and their relevance for cancer metastasis, funded by a Worldwide Cancer Research 2020 grant. The current research of the lab is focused on mechanotransduction and how this regulates signaling and metabolism. The ideal candidate should have a PhD in the field of molecular biology, cell biology or metabolism and relevant publications. Previous experience in cell culture and imaging techniques is recommended. Enquiries and applications can be sent to sirio.dupont@unipd.it explaining why you are interested in joining the lab, including a CV with a brief research synopsis, and contact information for 2 references (name, address, email and phone number).Start date:December 2020.

A postdoctoral position is available in the RNA Biology of the Neuron unit directed by Dr. Jean-Michel Cioni at the San Raffaele Institute, Milan.