Circular RNAs (CircRNAs) are a rediscovered class of RNA species that originate from back-splicing events, which have been reported across all domains of life. Many circRNAs are stable, abundant and conserved between species. They exhibit context-dependent expression patterns, which are often linked to disease states. Validated circular RNA functions are numerous and range from regulation of transcription and splicing to RNA/protein sponging and scaffolding. However, CircRNAs are by-an-large the most under-explored class of all non-coding RNAs. This course will meet the specific need to explore complexity, distribution, function, mechanisms of action, and therapeutic use of circRNAs, both experimentally and computationally.

This EMBO Practical Course focuses on cutting-edge methods and approaches that are widely applicable to all organisms beyond standard models. Lectures will cover the technological background of circular RNA research and present the latest advancements from biology, chemistry and medicine. The practical part will include detection and quantification of circRNAs by low- and high-throughput methods, data analysis and integration as well as comprehensive computational assessment of circRNA candidates, function prediction and experimental design of follow-up experiments. Each building block features extensive Q&A and troubleshooting slots with emphasis on best practice. Finally, group activities and networking opportunities will create a unique experience.

INFO & REGISTRATION: https://meetings.embo.org/event/25-circ-rna

DEADLINE: 1st of February 2025