ABCD 2021 ABCD 2021
Biology of the cancer cell
Francesco Cecconi
Autophagy and E3 ligases: top guardians of cell cycle

click to open video 2021 - 1920 x 1080

James DeGregori
Targeting ATM kinase and mTORC1 signaling reverses bone marrow stromal cell-mediated protection of FLT3-ITD AML from FLT3 targeted therapy

click to open video 1736 - 1920 x 1080

Gillian Griffiths
Cancer assassins: dynamic regulation of polarized secretion

click to open video 1772 - 1920 x 1080

Johanna Ivaska
Endosomal trafficking in breast cancer progression and drug resistance

click to open video 1942 - 1334 x 720

Sima Lev
Exploiting ferroptosis for cancer therapy: focus on TNBC

click to open video 2487 - 1920 x 1080

Massimiliano Mazzone
Harnessing tumor metabolism to overcome immunosuppression

click to open video 1646 - 1920 x 1080

Marta Miączyńska
GAS6-AXL signaling in cancer cell biology

click to open video 1722 - 1920 x 1080

Erik Sahai
Novel mechanisms of tumor microenvironment crosstalk supporting breast cancer dormancy

click to open video 2060 - 1920 x 1080

Biology revealed through advanced Imaging
Jan Ellenberg
Advanced imaging of cellular processes across scales

click to open video 2053 - 1920 x 1080

Tom Kirchhausen
Mitotic assembly of nuclear pore complexes

click to open video 2052 - 1910 x 1058

Jennifer Lippincott-Schwartz
Inspecting the secretory pathway with whole-cell, volumetric FIB-SEM

click to open video 1701 - 3684 x 1440

ABCD Distinguished Lecture Series - Sponsor
Cell metabolism
Ralph DeBerardinis
Metabolic Outliers in Human Disease

click to open video 1748 - 1920 x 1080

Ayelet Erez
Modulating amino-acid metabolism for cancer diagnosis and therapy

click to open video 1841 - 1920 x 1080

Robert Farese & Tobias Walther
Mechanisms and Physiology of Lipid Storage in Lipid Droplets

click to open video 3342 - 1366 x 700

Christian Frezza
Fumarate Hydratase loss as a paradigm of oncometabolism

click to open video 2017 - 1440 x 1080

Cristina Muñoz Pinedo
Metabolic stress drives inflammation

click to open video 1972 - 1920 x 1040

Roberto Zoncu
The Lysosome in Nutrient Sensing and Cellular Growth Control

click to open video 2665 - 1152 x 720

ABCD Distinguished Lecture Series - Sponsor
Cell plasticity, motility and mechanosensing
Sandrine Etienne-Manneville
Role of microtubules in mechanosensitive cell responses

click to open video 1880 - 1920 x 1080

Guillaume Montagnac
Associative memory in mammalian cells in culture

click to open video 2791 - 1920 x 1080

Jim Norman
Nuclear-capture of endosomes drives depletion of nuclear G-actin to activate SRF and drive invasiveness

click to open video 2428 - 1680 x 1050

Martin Schwartz
Mechanical homeostasis in the cardiovascular system

click to open video 1785 - 1920 x 1080

Endocytosis
Frances Brodsky
Genetic Diversity of Clathrin Subunits Enables Tissue-Specific Functions

click to open video 2391 - 1440 x 1080

Ludger Johannes
Lectin-driven and glycosphingolipid-dependent construction of endocytic pits: GL-Lect hypothesis

click to open video 1909 - 1458 x 1080

Sandy Schmid
The plasticity and robustness of clathrin-mediated endocytosis

click to open video 2241 - 1152 x 720

Sara Sigismund
Endocytosis and interorganelle communication: connecting EGFR signalling to cell metabolism

click to open video 2051 - 1920 x 1080

Alexander Sorkin
EGFR endocytosis

click to open video 2230 - 1920 x 1080

Harald Stenmark
Macropinocytosis - functions and mechanisms

click to open video 1786 - 2560 x 1440

Genome architecture and chromosome segregation
Wendy Bickmore
The remote control of gene expression: enhancer function in the cell nucleus

click to open video 2159 - 1920 x 1080

Arshad Desai
Targeting cancer-specific cell division vulnerability

click to open video 1908 - 1366 x 684

Rebecca Heald
Investigating mechanisms of cell division and size control in Xenopus

click to open video 2630 - 1680 x 1050

Tom Misteli
Genome Architecture: From basics to disease

click to open video 2722 - 2688 x 1240

Membrane trafficking
Antonella De Matteis
ER-Golgi membrane contact sites

click to open video 1770 - 1152 x 720

Bruno Goud
Multiple roles of the RAB6 GTPase in transport at the Golgi level

click to open video 1616 - 1152 x 720

Volker Haucke
Lipid and protein switches in cell physiology: From mechanisms to disease

click to open video 3087 - 2560 x 1440

Graça Raposo
Extracellular Vesicles integrators of homeostasis, lessons from immunity and pigmentation

click to open video 1739 - 1152 x 720

Chiara Zurzolo
Role of Tunneling Nanotubes (TNTs) in the spreading of amyloid proteins in neurodegenerative diseases, and beyond

click to open video 2128 - 1920 x 1080

Mitochondria in health and disease
Michelangelo Campanella
Autophagy of mitochondria and their social habits in health and disease

click to open video 1967 - 1152 x 720

Lorenzo Galluzzi
Mitochondrial control of anticancer immune responses driven by radiation

click to open video 1456 - 3840 x 2160

Thomas Langer
Proteolytic Control of Mitochondrial Plasticity

click to open video 1887 - 1366 x 668

Richard Youle
Intertwined Roles of Two Parkinsons Disease Genes in Autophagy of Mitochondria and Inflammation

click to open video 2293 - 1904 x 1050

Morphogenesis from cells to systems
Annika Guse
Adaptation to the environment by coral-algal endosymbiosis - a cell biological perspective

click to open video 2089 - 1920 x 1080

Nereo Kalebic
Neural stem cells and neocortex expansion in brain development and evolution.

click to open video 1965 - 1280 x 720

Susan Mango
Morphogenesis in the nucleus

click to open video 1830 - 2560 x 1440

Mark Peifer
Building the Body Plan: the Miracle of Morphogenesis

click to open video 2654 - 2560 x 1440

Aurélien Roux
Morphogenesis of cellular tornadoes

click to open video 1772 - 1680 x 1050

Kenneth Yamada
Cell and Matrix Dynamics in Cell Migration and Organ Morphogenesis

click to open video 2054 - 1920 x 1080

Marino Zerial
Mechanisms of hepatocyte polarization and liver tissue morphogenesis

click to open video 1760 - 2732 x 1262

Protein folding and degradation
Hesso Farhan
Regulation of ER-proteostasis through a Folded Protein Response

click to open video 1950 - 2304 x 1440

Ilaria Fregno
ER-to-lysosome Associated Degradation (ERLAD) of proteasome-resistant misfolded proteins

click to open video 1620 - 1152 x 720

Signal transduction
Manuela Baccarini
Navigating the ERK pathway through protein-protein interactions

click to open video 2466 - 1920 x 1080

Christophe Lamaze
MechanoTransduction by caveolae

click to open video 2128 - 1680 x 1050

Daniel B. Rifkin
Latent TGF beta binding protein biology

click to open video 2094 - 1920 x 1080

Lois Weisman
Regulation of a receptor recycling pathway via a phosphoinositide cascade

click to open video 2296 - 2560 x 1440

Understanding biology at the ultrastructural level
Lucia Banci
Cellular Structural Biology: from Protein Structures to Functional Processes in a Cellular Context

click to open video 2175 - 1330 x 720

James Hurley
Structural gymnastics of the Rag GTPase cycle on lysosomes

click to open video 1891 - 1152 x 720

Eva Nogales
Structural Studies of Microtubule Dynamics and Function

click to open video 1814 - 1152 x 720