The mitochondrial permeability transition (MPT) refers to an alteration of the permeability of the inner mitochondrial membrane and was characterized for the first time in 1979.

E' con estremo piacere - e malcelato orgoglio - che desideriamo informarvi che proprio ieri ABCD ha raggiunto il traguardo dei 500 iscritti all'Associazione.

The Telethon Institute of Genetics and Medicine (TIGEM) was created in 1994 by the Telethon Foundation to promote the advancement of research aimed at the diagnosis, prevention and cure of human genetic diseases.

In the early 90’s one of the most fascinating mysteries of biology attracted my curiosity: the cell’s ability to commit suicide. In my view, the existence of a specific genetic program devoted to regulate the death of a cell is something, still exciting today. At that time identification of genes and the definition of the signaling pathways, controlling cell death was a sort of gold rush.

Which are the molecular mechanisms that cause the Down syndrome (DS) phenotype?